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GHRH-analog research · 4 articles

Tesamorelin

Tesamorelin (stabilized GHRH(1-44) analog / GHRH receptor agonist peptide) · 5 min read

Tesamorelin is a synthetic 44-amino-acid analog of human growth-hormone-releasing hormone (GHRH(1-44)) bearing a trans-3-hexenoyl modification on the N-terminal tyrosine. In research settings it is handled as a well-characterized peptide reference material (PubChem CID 16137828; CAS 218949-48-5; C₂₂₁H₃₆₆N₇₂O₆₇S; ~5135.86 g/mol) for in-vitro study of GHRH-receptor signaling, peptide-stability chemistry, and analytical identity. This listing is strictly Research Use Only and is not intended for any human or veterinary application.

Analytical identity

Supplied as a lyophilized powder characterized to ≥98% (HPLC). The molecule corresponds to PubChem CID 16137828 (CAS 218949-48-5), with molecular formula C₂₂₁H₃₆₆N₇₂O₆₇S and a reported monoisotopic/average molecular weight near 5135.86 g/mol. Identity and purity are typically confirmed by reversed-phase HPLC and mass spectrometry against the expected sequence and the N-terminal trans-3-hexenoyl modification.

Structure and sequence

The peptide reproduces the full 44-residue sequence of human GHRH(1-44) and carries a trans-3-hexenoyl (C6) acyl group anchored to the N-terminal tyrosine. This N-terminal modification is described in the literature as a structural feature that increases resistance to dipeptidyl-peptidase-mediated cleavage relative to the unmodified peptide, a property of interest in analog-stability and structure-activity chemistry studies.

Mechanism themes in the literature

Research literature characterizes tesamorelin as a GHRH-receptor (GHRHR) agonist. In cell-based and biochemical model systems it is discussed in the context of Gs-coupled adenylyl-cyclase activation and cAMP-dependent signal transduction within somatotrope-axis (GH/IGF-1) pathway models. These mechanism themes are presented for in-vitro investigational context only.

Research context and handling

Used by laboratories as a comparator and reference standard for GHRH-analog receptor-pharmacology assays, peptide-stability experiments, and analytical method development. Store the lyophilized material desiccated and protected from light; consult literature via the PubChem and PubMed references for characterization data. For laboratory research use only — not for human or veterinary use, and not for diagnostic or therapeutic purposes.

Documented in every box

Every Tesamorelin order includes a sealed, lot-controlled vial, the completed lot documentation, and a handling & storage card. Product-specific handling follows the supplied documentation and institutional SOPs.

Evidence limits and research safety

Research findings can differ by model, assay, purity, formulation, and study design. Published cell, biochemical, and pre-clinical observations do not establish human or veterinary safety, efficacy, dosing, or suitability. Researchers should review the applicable SDS, institutional safety procedures, waste requirements, and lot-specific documentation before handling any reference material.

Related research

CJC-1295 / Ipamorelin (no DAC)

Credible sources

Research context only. This article summarizes published in-vitro and pre-clinical research for scientific context. It is not a claim of efficacy or safety and does not constitute medical, usage, or dosing guidance. HELIX BioScience products are Research Use Only and not for human or veterinary use.

More on Tesamorelin

Methods note

Tesamorelin: a peptide identity workflow

Tesamorelin: a peptide identity workflow explains how a laboratory team can frame Tesamorelin as a characterized research reference for linking sequence records, expected mass, and chromatographic evidence in an identity review. The emphasis is on reproducible preparation, analytical controls, and careful interpretation—not on therapeutic, diagnostic, or in-vivo use.

7 min read
Methods note

Tesamorelin: matrix-interference review

Tesamorelin: matrix-interference review explains how a laboratory team can frame Tesamorelin as a characterized research reference for checking whether a research matrix changes the analytical signal attributed to the peptide. The emphasis is on reproducible preparation, analytical controls, and careful interpretation—not on therapeutic, diagnostic, or in-vivo use.

7 min read
Methods note

Tesamorelin: raw-data review checklist

Tesamorelin: raw-data review checklist explains how a laboratory team can frame Tesamorelin as a characterized research reference for reviewing raw traces and run metadata before accepting a peptide comparison. The emphasis is on reproducible preparation, analytical controls, and careful interpretation—not on therapeutic, diagnostic, or in-vivo use.

7 min read