Semax
Semax (synthetic ACTH(4-7)-PGP heptapeptide analog) · ≥98% (HPLC)
Semax is a synthetic heptapeptide analog of an adrenocorticotropic hormone (ACTH) fragment, supplied as a characterized reference material for in-vitro neurotrophic-signaling research. Research Use Only.
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Research profile & documentation
- Why researchers study it
- Studied in vitro as a synthetic ACTH-fragment analog used to investigate neurotrophic-factor gene-expression pathways independent of the native hormone's adrenocorticotropic activity.
- Mechanism themes in research
- BDNF (brain-derived neurotrophic factor) expression signaling studiesACTH(4-7) fragment structure-activity chemistryCentral-nervous-system neurotrophic-pathway cell modelsAnalytical reference standard for identity and purity (HPLC/MS)
- What the evidence does not establish
- Published references are in-vitro or pre-clinical and describe research context only. They do not establish safety, efficacy, or any outcome in humans or animals, and Helix makes no such claims.
- Quality markers
- ≥98% (HPLC)MS identityLot COACold-chain
- What ships
- The sealed lot-controlled vial, a measured ampoule of bacteriostatic water, and a printed handling & reconstitution card — plus the per-lot COA. Everything to prepare it, in one box.
An introduction to Semax, a heptapeptide ACTH(4-10) analog reference material studied in neuropeptide research.
What it is
Semax is a synthetic heptapeptide and an analog of the ACTH(4-10) sequence, supplied strictly as a research-use-only reference material. It is catalogued under the neuropeptide category and identified analytically by CAS number 80714-61-0 and a molecular weight near 813.9 g/mol with a purity specification of not less than 98% by HPLC.
Relationship to ACTH(4-10)
Semax derives from the ACTH(4-10) fragment, modified with a Pro-Gly-Pro tail at the carboxyl terminus. This terminal extension is a defining structural feature that distinguishes the analog from the native fragment and is associated with greater resistance to enzymatic breakdown in research settings.
| Full name | Semax (synthetic ACTH(4-7)-PGP heptapeptide analog) |
| Research theme | Neuropeptide & cognition |
| CAS number | 80714-61-0 |
| Molecular formula | C₃₇H₅₁N₉O₁₀S |
| Molecular weight | 813.9 g/mol |
| Purity | ≥98% (HPLC) |
| Physical form | Lyophilized powder |
| Storage | −20 °C, desiccated, protected from light |
Sequence
Reported research areas
- Central nervous system neurotrophic-factor signaling (BDNF expression) studies
- ACTH-fragment structure-activity chemistry
- Peptide stability and analytical characterization
- Analytical reference standard for identity and purity (HPLC/MS)
Credible sources
COA with every lot
Each Semax lot is characterized by reversed-phase HPLC for purity and by mass spectrometry for identity, then documented in a per-lot Certificate of Analysis. Unique lot numbers tie the vial back to its synthesis batch and analytical data.
- RP-HPLC purity result (≥98% (HPLC))
- Mass-spectrometry identity confirmation
- Appearance, molecular weight, and storage
- Lot number and testing status
Specimen Certificate of Analysis
| Product | Semax (reference) |
| Lot | HXR-2406-117 |
| Purity (RP-HPLC) | 98%+ |
| Identity (MS) | Confirmed · 813.9 g/mol |
| Appearance | Lyophilized powder |
| Storage | −20 °C, desiccated |
Representative document. Each lot has its own COA — these are quality documents, not medical claims.
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