Research Use Only — documentation confirmed by inquiry
MOTS-c
| Units | Discount |
|---|---|
| 1–2 | 0% |
| 3–4 | 10% |
| 5–6 | 15% |
| 7–9 | 20% |
| 10–+ | 30% |
MOTS-c (mitochondrial open reading frame of the 12S rRNA-c; 16-aa mitochondrial-derived peptide) · ≥98% (HPLC)
MOTS-c is a 16-amino-acid mitochondrial-derived peptide supplied as a characterized reference material for in-vitro mitochondrial-signaling and metabolic-pathway research. Research Use Only.
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Research context and documentation
- Why researchers study it
- MOTS-c is studied as a model mitochondrial-derived peptide for investigating retrograde mitochondrial-to-nuclear signaling and the regulation of cellular energy-sensing pathways in cell and tissue models.
- Mechanism themes in research
- AMPK energy-sensing pathway modulation (Folate–AICAR–AMPK axis)Retrograde mitochondrial-to-nuclear signaling and nuclear translocation under metabolic stressNrf2/antioxidant-response gene-expression regulationGlucose-metabolism and GLUT4-translocation signaling in skeletal-muscle cell models
- What the evidence does not establish
- Published references describe research context only. They do not establish safety, efficacy, biological activity, or any outcome in humans or animals, and HELIX BioScience makes no such claims.
- Quality markers
- ≥98% (HPLC)MS contextCOA statusStorage stated where verified
- Documentation status
- Product specifications and COA status are shown on this page. Current lot documentation is provided when issued and matched to the offered lot.
MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA (MT-RNR1) region. It is offered as a lyophilized, HPLC-characterized reference material for in-vitro research into mitochondrial signaling and cellular energy-sensing pathways. This listing is for laboratory Research Use Only and is not for human or veterinary use.
Analytical identity
Supplied as a lyophilized powder at ≥98% (HPLC) purity. The peptide carries the canonical 16-residue sequence MRWQEMGYIFYPRKLR (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg), molecular formula C₁₀₁H₁₅₂N₂₈O₂₂S₂, and a monoisotopic/average molecular weight near 2174.6 g/mol (PubChem CID 146675088). Identity and purity are characterized by HPLC and mass spectrometry for use as an analytical reference standard.
Literature mechanism themes
In the research literature, MOTS-c is described as a mitochondrial-derived peptide that engages the AMPK energy-sensing pathway, reported in cell and tissue models to act through the folate–AICAR–AMPK axis. It is also studied for retrograde mitochondrial-to-nuclear signaling, including nuclear translocation under metabolic stress and modulation of Nrf2-linked antioxidant-response gene expression. These mechanisms are summarized here only as published research themes describing in-vitro and model-system observations.
| Full name | MOTS-c (mitochondrial open reading frame of the 12S rRNA-c; 16-aa mitochondrial-derived peptide) |
| Research theme | Mitochondrial & energy |
| CAS number | |
| Molecular formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
| Molecular weight | 2174.6 g/mol |
| Purity | ≥98% (HPLC) |
| Physical form | Lyophilized powder |
| Storage | −20 °C, desiccated, protected from light |
Sequence
Reported research areas
- Mitochondrial-derived peptide (MDP) biology
- Cellular energy-sensing and AMPK pathway studies
- Metabolic-homeostasis signaling in vitro
- Mitochondrial retrograde-signaling and gene-expression research
Credible sources
- PubChem — MOTS-c (CID 146675088)
- PubMed — MOTS-c mitochondrial-derived peptide literature
- PMC — MOTS-c: effects and mechanisms in stress, metabolism and aging
COA status shown
Request the current documentation packet for the offered material. When available, it identifies the reported HPLC result and any identity method; public product specifications are not current lot results.
- HPLC result, when reported
- Identity method, when reported
- Appearance, molecular weight, and storage where documented
- Lot number and testing status
Specimen Certificate of Analysis
| Product | MOTS-c (reference) |
| Status | Format preview — not a current lot |
| Purity (RP-HPLC) | 98%+ |
| Identity (MS) | Confirmed · 2174.6 g/mol |
| Appearance | Lyophilized powder |
| Storage | −20 °C, desiccated |
Format preview only. Current lot records and measured results are not published here until supplied and verified.
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